Changing gene expression
Gene Therapy is the next generation treatment. It can be used to replaced a mutated gene that causes disease with a healthy copy of the gene; inactivate or “knocking out,” a mutated gene that is functioning improperly. -to modulate expression of specific genes- or introduced a new gene into the body to help fight a disease- like genetic vaccines.
IN PRECISION GLYCOSCIENCES WE TAKE ADVANTAGE OF THE MULTIVALENT INTERACTIONS OF GLYCOPOLYMERS WITH THE CELLS TO DEVELOP EFFECTIVE AND SPECIFIC VEHICLES FOR GENE THERAPY.
Glycopolymers as Delivery Vectors
Low Immunogenicity
Facile Manufactuting
Targeting Capabilities
Low Cost
Efficient transfection
Overcoming challenges with Glycopolymers
reduce the charge density of the polyplexes without harming their RNA-condensing capacity and stability.
Stimuli-responsive
Endosomal Cleavage
Membrane Fusion and
cytoplasmic delivery
Controlled release of cargo
Design Plasticity
Amphiphilic
Reduce Immune Responses
Zwitterionic charges
Prolong circulation Time
Reduce Toxicity
Reduce
non-specific interactions
Biodegradable
Mimick Natural Glycans
High Biocompatibility
Effective Cellular Uptake
Multivalency Interactions
with cell membrane
receptors
(lectin-carbohydrate
recognition)
Advanced Glycopolymer Formulations
01
Acid degradable Hyperbranched Glycopolymers
02
Tumour microenvironment responsive Hyperbranched Glycopolymers
03
Sugar responsive Hyperbranched Glycopolymers.
04
Stimuli-responsive Nanogels
•Protection of DNA, RNA, siRNA, Drugs
•Easy administration
•Serum stability
•Targetability to specific cell types
•Ease internalization
•Efficient unpackaging
•Non-toxic, non-immunogenic,
non-pathogenic
